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PrEP, PEP & nPEP


PrEP (Pre-Exposure Prophylaxis)  A comprehensive HIV prevention strategy that involves the daily use of antiretroviral medications to reduce the risk of HIV infection in HIV-negative individuals.

PEP (Post-Exposure Prophylaxis) Taking antiretroviral medicines (ART) after being potentially exposed to HIV to prevent becoming infected.

nPEP (Non-occupational Post-Exposure Prophylaxis) Short-term treatment started as soon as possible after high-risk non-occupational exposure to an infectious agent, such as HIV, hepatitis B virus (HBV), or hepatitis C virus (HCV).


Featured Event!

  • October 27: Miami PrEP Implementation Summit  The Florida Department of Health in Miami-Dade County and the Miami PrEP Workgroup are excited to invite you to the virtual Miami PrEP Implementation Summit on Wednesday, October 27th, 2021 from 2:00-4:00pm!  Attendees will have the opportunity to hear from experienced PrEP providers and content experts on best practices for providing PrEP care in Miami-Dade County. The event will feature three presentations from leading experts on PrEP care in Miami-Dade County on barriers to care they encountered and how they overcame these obstacles. A local content expert will then present on how to build a protocol and share best practices. The event will conclude with a PrEP implementation case study and Q&A session.

COVID-19 PrEP Access Updates

News & Resources

  • Pharmacy-Initiated PrEP and PEP* (nastad.org) NASTAD is pleased to announce the publication of a new resource, Pharmacy-Initiated PrEP and PEP. This resource was developed after researching various proposed and enacted bills throughout the country related to pharmacist’s ability to dispense Pre-Exposure Prophylaxis (PrEP) and (Post-Exposure Prophylaxis) PEP without a prescription from a medical provider.
  • NASTAD PrEP Coverage Brief: PrEP Services Covered with No Cost-Sharing. This National Alliance of State and Territorial AIDS Directors (NASTAD) fact sheet walks through the coverage and cost-sharing requirements for public and private payers that come with this USPSTF Grade A recommendation. It summarizes federal guidance on implementing Preventive Services provisions of the Affordable Care Act (ACA), including new federal sub-regulatory guidance addressing PrEP services released on July 19, 2021. Contact NASTAD’s PrEP team at PrEP@NASTAD.org with questions or to request TA on PrEP financing and coverage.
  • HIV Prevention Certified Provider Program HealthHIV has added a new module on PrEP Adherence to its HIV PCP program and is offering free, continuing education credits for its completion. The HIV Prevention Certified Provider Program is an online, self-paced CME curriculum composed of six modules in HIV prevention detailing the pertinent clinical and practice information that clinicians need to effectively employ HIV prevention interventions. Upon successful completion of this program, participants earn a certificate recognizing their designation as an HIV Prevention Certified Provider (HIV PCP) and receive listing in national online directory of HIV PCPs. The curriculum is updated annually and more frequently as needed, based on approval of new biomedical interventions and release of evidence-based practices.
  • Persons at high risk of HIV acquisition* The US Preventive Services Taskforce (USPSTF) recommends that clinicians offer pre-exposure prophylaxis (PrEP) with effective antiretroviral therapy to persons who are at high risk of HIV acquisition.
  • Best Practices: Interventions for PrEP* The Centers for Disease Control and Prevention (CDC HIV/AIDS Prevention Research Synthesis (PRS) Project) identifies evidence-based interventions (EBIs) and evidence-informed interventions (EIs) for the Compendium of Evidence-Based Interventions and Best Practices for HIV Prevention. The Compendium helps HIV prevention planners and providers in the United States (US) select interventions most appropriate for their communities. The Compendium contains chapters on risk reduction; medication adherence; linkage to, retention in, and re-engagement in HIV care; and structural interventions. (February 2021)
  • HealthHIV becomes the new home for PleasePrEPMe.org, the original comprehensive PrEP online resource*  As of Friday, January 15, 2021, HealthHIV will be the new home of PleasePrEPMe.org, an online platform that expands access to pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP). Initially launched in 2015 as a searchable and location-responsive provider directory for the State of California, PleasePrEPMe.org has expanded to provide HIV prevention resources in English and Spanish for consumers and providers in all 50 states. The platform features an online PrEP navigation training program with multiple modules/courses and downloadable resources which offer comprehensive insights and highlight best practices for PrEP consumers, navigators, and prescribers. (January 2021)
  • HHS Seeks Vendor(s) to Distribute PrEP Medications as Part of Ready, Set, PrEP* (HIV.gov) The U.S. Department of Health & Human Services (HHS) requires a vendor(s) to distribute pre-exposure prophylaxis (PrEP) medications as part of a donation agreement between HHS and Gilead to provide PrEP medication at no cost for up to 200,000 individuals a year who are at risk for HIV and who are uninsured.
  • Ready, Set, PrEP Expands Access to Medication to Prevent HIV *  HRSA News December 3 – The U.S. Department of Health and Human Services (HHS) today launched Ready, Set, PrEP, a national program that makes medications for pre-exposure prophylaxis (PrEP), taken daily to prevent HIV, available at no cost to people without prescription drug insurance coverage.

This page includes links to Ryan White Program and non-Ryan White Program funded services. Please contact your Medical Case Manager with questions about Ryan White Program eligibility.

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