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PrEP, PEP & nPEP

PrEP (Pre-Exposure Prophylaxis)  A comprehensive HIV prevention strategy that involves the daily use of antiretroviral medications to reduce the risk of HIV infection in HIV-negative individuals.

PEP (Post-Exposure Prophylaxis) Taking antiretroviral medicines (ART) after being potentially exposed to HIV to prevent becoming infected.

nPEP (Non-occupational Post-Exposure Prophylaxis) Short-term treatment started as soon as possible after high-risk non-occupational exposure to an infectious agent, such as HIV, hepatitis B virus (HBV), or hepatitis C virus (HCV).

Find PrEP and PEP Near You!

News & Resources

  • Barriers and Facilitators to Expanding PrEP Coverage in Southern Ending the HIV Epidemic States and Jurisdictions* A survey for health providers, programmers and public health practitioners. Southern AIDS Coalition in partnership with PrEP4All, is conducting a rapid landscaping to identify laws, policies and administrative requirements and approaches that impact PrEP access in the South. The analysis will center on coverage of costs, network sufficiency and community knowledge and demand. Information provided in this survey will be used to compile a non-exhaustive list of policies, requirements and approaches that can be used to guide recommendations, advocacy and implementation. Information provided here will be treated as anonymous and may be described in a summary report in aggregate–ie “X number of states have a specific policy or issue impacting coverage.” Information about your role, location and affiliation will be used for internal purposes and to share the results of this work and future activities. If you have questions or concerns please contact Michael@PrEP4All.org.
  • Ready, Set PrEP* at Care 4 U Community Health Center Be PrEPared! Care 4 U new patient PrEP opportunity. Earn $50 a month!
  • Task Force Issues Draft Recommendation Statement on PrEP for HIV Prevention, Invites Public Comment* (HIV.gov, December 13, 2022) Healthcare professionals should prescribe pre-exposure prophylaxis (PrEP) to people at increased risk for HIV.  The U.S. Preventive Services Task Force (Task Force) today posted a draft recommendation statement on pre-exposure prophylaxis (PrEP) for the prevention of HIV infection. Based on its review of the evidence, the Task Force recommends that healthcare professionals prescribe PrEP to people at increased risk for HIV to help prevent HIV infection. This is an A grade. 
  • NASTAD PrEP Coverage Brief: PrEP Services Covered with No Cost-Sharing* (nastad.org, July 22, 2021) This National Alliance of State and Territorial AIDS Directors (NASTAD) fact sheet walks through the coverage and cost-sharing requirements for public and private payers that come with this USPSTF Grade A recommendation. It summarizes federal guidance on implementing Preventive Services provisions of the Affordable Care Act (ACA), including new federal sub-regulatory guidance addressing PrEP services released on July 19, 2021. Contact NASTAD’s PrEP team at PrEP@NASTAD.org with questions or to request TA on PrEP financing and coverage.
  • HIV Prevention Certified Provider Program* HealthHIV has added a new module on PrEP Adherence to its HIV PCP program and is offering free, continuing education credits for its completion. The HIV Prevention Certified Provider Program is an online, self-paced CME curriculum composed of six modules in HIV prevention detailing the pertinent clinical and practice information that clinicians need to effectively employ HIV prevention interventions. Upon successful completion of this program, participants earn a certificate recognizing their designation as an HIV Prevention Certified Provider (HIV PCP) and receive listing in national online directory of HIV PCPs. The curriculum is updated annually and more frequently as needed, based on approval of new biomedical interventions and release of evidence-based practices.
  • Persons at high risk of HIV acquisition* (nastad.org, January 1, 2022) The US Preventive Services Taskforce (USPSTF) recommends that clinicians offer pre-exposure prophylaxis (PrEP) with effective antiretroviral therapy to persons who are at high risk of HIV acquisition.
  • Best Practices: Interventions for PrEP* (HIV.gov, January 11, 2021) The Centers for Disease Control and Prevention (CDC HIV/AIDS Prevention Research Synthesis (PRS) Project) identifies evidence-based interventions (EBIs) and evidence-informed interventions (EIs) for the Compendium of Evidence-Based Interventions and Best Practices for HIV Prevention. The Compendium helps HIV prevention planners and providers in the United States (US) select interventions most appropriate for their communities. The Compendium contains chapters on risk reduction; medication adherence; linkage to, retention in, and re-engagement in HIV care; and structural interventions. (February 2021)
  • HealthHIV becomes the new home for PleasePrEPMe.org, the original comprehensive PrEP online resource*  As of Friday, January 15, 2021, HealthHIV will be the new home of PleasePrEPMe.org, an online platform that expands access to pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP). Initially launched in 2015 as a searchable and location-responsive provider directory for the State of California, PleasePrEPMe.org has expanded to provide HIV prevention resources in English and Spanish for consumers and providers in all 50 states. The platform features an online PrEP navigation training program with multiple modules/courses and downloadable resources which offer comprehensive insights and highlight best practices for PrEP consumers, navigators, and prescribers. (January 2021)

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